期刊
FEMS MICROBIOLOGY LETTERS
卷 253, 期 1, 页码 95-101出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2005.09.028
关键词
Pseudomonas aeruginosa; type III secretion; needle; PscF; YscF
类别
Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen, translocates exoenzymes (Exo) directly into the eukaryotic cell cytoplasm. This is accomplished by a type III secretion/translocation machinery. Here, we show that the P. aeruginosa type III secretory needle structure is composed essentially of PscF, a protein required for secretion and P. aeruginosa cytotoxicity. Partially purified needles, detached from the bacterial surface, are 60-80 nm in length and 7 nm in width, resembling needles from Yersinia spp.. YscF of Yersinia enterocolitica was able to functionally complement the pscF deletion, but required 11 P. aeruginosa-specific amino acids at the N-terminus for its function. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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