期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 5, 期 12, 页码 1125-1132出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955705774933356
关键词
prostate cancer; PI3K/Akt/mTOR pathway; growth inhibition
This review presents some therapeutic interventions actually considered in prostate cancer therapy to compensate constitutive activation of the PI3K/Akt signalling pathway induced, particularly, by mutations of PTEN gene. Special emphasis is placed on applicability of EGF-R tyrosine kinase, COX-2, PDK-1, mTOR and farnesyltransferase inhibitors.
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