期刊
BRAIN RESEARCH REVIEWS
卷 50, 期 1, 页码 14-26出版社
ELSEVIER
DOI: 10.1016/j.brainresrev.2005.04.002
关键词
HIV-dementia; Tat; oxidative stress; antioxidant
资金
- NCRR NIH HHS [P20 RR15592] Funding Source: Medline
- NIA NIH HHS [AG-10836, AG-05119] Funding Source: Medline
- NIMH NIH HHS [MH64409] Funding Source: Medline
- NINDS NIH HHS [R01 NS39253] Funding Source: Medline
Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed. (c) 2005 Elsevier B.V. All rights reserved.
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