期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 116, 期 6, 页码 1202-1205出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2005.08.050
关键词
asthma; atopy; hygiene hypothesis; regulatory T cell; pathogen-associated molecular patterns
资金
- NHLBI NIH HHS [R21HL079447, R21HL079448, R01 HL59324] Funding Source: Medline
- NIEHS NIH HHS [P01 ES0009607] Funding Source: Medline
Asthma and atopy are characterized by T(H)2-type patterns of inflammation. The hygiene hypothesis suggests that early-life environmental exposure to microbes, other pathogens, and their products promotes innate immune responses that suppress atopy; the current epidemic of allergic disease may result from a dearth of such stimuli. Antiatopic responses engendered by these exposures include both T(H)1-type and regulatory-type patterns, the latter including mechanisms of antigen-presenting cells as well as those of lymphoid origin, and are characterized by prominent IL-10 and/or TGF-beta effects. The Toll-like receptors are an important family of innate immune response elements that have many similar structural and functional properties, but have evolved to recognize distinct ligands as well as to be expressed differentially on immune cells. An active and productive area of current research is investigating the utility of microbes and microbial products for modulation of inflammation in asthma and atopic disorders. Clinical trials have been conducted for some of these biologic compounds, such as cytosine-guanine dinucleotide DNA and Mycobacterium vaccae, whereas others remain in preclinical testing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据