期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 82, 期 6, 页码 1346-1352出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/82.6.1346
关键词
folate; homocysteine; cognitive function; dementia; Modified Mini-Mental State Examination; vitamin B-12; creatinine; Center for Epidemiologic Studies Depression scale; elderly; aging; Latinos
资金
- NIA NIH HHS [R03 AG033751, R01 AG012975, AG10129, AG10220, AG12975] Funding Source: Medline
- NIDDK NIH HHS [R01 DK060753] Funding Source: Medline
Background: Low folate status is associated with poor cognitive function and dementia in the elderly. Since 1998, grain products in the United States have been fortified with folic acid, which has reduced the prevalence of folate deficiency and hyperhomocysteinemia. Objective: We investigated whether folate status is associated with cognitive function and dementia in a cohort of elderly Latinos (aged >= 60 y; n = 1789) exposed to folic acid fortification. Design: Global cognitive function was assessed by the Modified Mini-Mental State Examination (3MSE) and specific cognitive functions by cross-culturally validated neuropsychological tests. Dementia was diagnosed according to the American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, 3rd edition revised, and California Alzheimer Disease Diagnostic and Treatment criteria. Red blood cell (RBC) folate was measured by automated chemiluminescence and total plasma homocysteine by HPLC. Results: The prevalence of folate deficiency (RBC folate <= 160 ng/mL) was <1%. After control for confounding by homocysteine, vitamin B-12, creatinine, demographic variables, and depressive symptom score, RBC folate was directly associated with 3MSE (P = 0.005) and delayed recall (P = 0.007) scores. In addition, adjusted odds ratios for low 3MSE score (!;78) and dementia diagnosis per unit increase in RBC folate were significantly below unity (P 0.008), which indicated that the relative risks of cognitive impairment and dementia decreased with increasing RBC folate concentration. In contrast, adjusted odds ratios for low 3MSE score and dementia diagnosis per unit increase in homocysteine were not significant. Conclusion: RBC folate is directly associated with cognitive function scores and is inversely associated with dementia in elderly Latinos despite folic acid fortification.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据