期刊
NEUROPEDIATRICS
卷 36, 期 6, 页码 357-365出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-872880
关键词
brain tumour; medulloblastoma; primitive neuroectodermal brain tumour; psychological adjustment; quality of life; long-term complication
To study the outcomes in long-term survivors of paediatric medulloblastoma (MB), we followed 51 consecutive children who were treated between 1980 and 2000 in a single institution. In 18 of 26 survivors (mean follow-up time 12.2 years), tumour control, neurological, endocrine, and neurocognitive complications and their impact on behavioural and psychological adjustment, and health-related quality of life (QoL) were comprehensively assessed using qualitative and quantitative measures. Endocrine deficits occurred in 61%, neurological complications in 72%, and significant school problems in 72%. All patients had significant deficits in neurocognitive functioning: attention and processing speed was impaired in 79%, learning and memory in 88%, language in 56%, visual perception in 50%, and executive functions in 64%. In comparison with healthy controls, social functioning was rated by the patients as the QoL dimension most affected. Parents' ratings were considerably lower than those of the patients. No MB survivor > 18 years of age (n = 12) had a boy- or girlfriend. Because of their treatment, including craniospinal radiotherapy, MB long-time survivors are not only at great risk for neurological, endocrine, and neurocognitive complications, but also of social isolation thereby decreasing self-rated QoL substantially.
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