期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 193, 期 6, 页码 1999-2003出版社
MOSBY, INC
DOI: 10.1016/j.ajog.2005.04.054
关键词
smoking; anti-inflammatory cytokine; cervix; pregnancy; inflammation
资金
- NCRR NIH HHS [M01-RR000056] Funding Source: Medline
- NICHD NIH HHS [1 R01 HD41663-01A1] Funding Source: Medline
Objective: Anti-inflammatory cytokines play a role in the lower genital tract immune defense. We examined the impact of cigarette smoking in pregnancy on the detection of the 3 most important anti-inflammatory cytokines (interleukin-4, -10, and -13) in the cervix. Study design: One hundred fourteen gravid women from 4 to 16 weeks of gestation without bacterial vaginosis or sexually transmitted disease were queried regarding demographic factors and smoking. Concentrations of cytokines were determined with a multiplex assay for cervical swabs. Results: There was a positive linear relationship between the number of cigarettes that were smoked per day and cervical concentrations of interleukin-4, -10, and -13 (P < .001 for each). Median concentrations of interleukin-4 and -10 were greater among women who smoked >= 20 cigarettes per day than among non-smokers or less heavy smokers (P < .05 for both). There was no difference in concentrations of proinflammatory cytokines between smokers and non-smokers. Conclusion: Cigarette smoking in pregnancy is associated with an increase of cervical anti-inflammatory cytokines without a commensurate increase of proinflammatory cytokines. This may have important impact on the host response to infection. (c) 2005 Mosby, Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据