期刊
BEHAVIORAL NEUROSCIENCE
卷 119, 期 6, 页码 1477-1483出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.119.6.1477
关键词
adolescent; anxiety; stress; restraint; bright light
资金
- NIAAA NIH HHS [R01 AA014339, K01 AA00298] Funding Source: Medline
The conditions under which age differences in anxiety are observed in rodents are unclear. These studies explored the influence of test condition on anxiety-like behavior in adolescent and adult rats using the light-dark box. Behavior was assessed under different illumination levels (30 or 60 lux) and after brief stress (restraint or bright light). Anxiety-like behavior did not differ in the 30-lux test but was increased in adolescents in the 60-lux test. Restraint increased anxiety-like behavior in adolescents, resulting in elevated anxiety-like behavior relative to adults. Bright light decreased anxiety-like behavior, possibly because of negative contrast or novelty-induced anxiolysis. These studies demonstrate that adolescents display increased anxiety-like behavior when test conditions are more aversive and following exposure to stress.
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