期刊
ANNALS OF THORACIC SURGERY
卷 95, 期 6, 页码 1946-1951出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.athoracsur.2012.12.014
关键词
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资金
- Cooperative Studies Program of the Department of Veterans Affairs Office of Research and Development
- Department of Veterans Affairs Central Office, Office of Patient Care Services
- Offices of Research and Development at the Northport Veterans Affairs Medical Center
- VA Eastern Colorado Healthcare System
Background. The relative benefits of performing coronary artery bypass graft surgery off-pump versus on-pump continue to be debated. A critical, patient-centered outcome is health-related quality of life; yet there has been limited evaluation in large-scale, multicenter trials of the off-pump versus on-pump impact upon quality of life. Methods. The Veterans Affairs Randomized On/Off Bypass trial randomized 2,203 nonemergent patients to off-pump or on-pump from February 2002 to May 2007. Patients completed a general quality of life survey (VR-36) and a disease-specific quality of life survey, the Seattle Angina Questionnaire (SAQ), prior to surgery, then again at 3 and 12 months post-bypass. Results. Of the 2,130 1-year survivors, 1,805 patients (85%) completed 1-year surveys. Randomization resulted in comparable baseline patient characteristics, including VR-36 and SAQ scores. At 3 months and 1-year post-procedure, there were no clinically relevant differences between off-pump and on-pump patients in any of the quality of life measures. Both groups had statistically significant, comparable improvements in the physical component scale of the VR-36, and in the SAQ scales. Conclusions. For this trial's male, low-to-moderate risk, veteran population, there were no significant differences between off-pump and on-pump with regard to 1-year general and disease-specific quality of life outcomes. Both treatment arms experienced some improvements by 3 months, with continued improvements through 1-year post-bypass. (C) 2013 by The Society of Thoracic Surgeons
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