期刊
SYNLETT
卷 -, 期 19, 页码 2958-2962出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-921889
关键词
stereoselective sialylation; alpha-glycoside; oligosaccharides; N-phthalyl group; fixed dipole effect
Highly alpha-selective sialylation of sialic acid N-phenyltrifluoroacetimidate with galactose acceptors, up to 100:0 and 92% for alpha(2-6)-sialoglycoside, while 97:3 and 77% for alpha(2-3)-sialoglycoside linkage formations, has been realized by introducing the C-5 N-phthalyl group on the donor. The 'fixed dipole effect' of N-phthalyl group was proposed in order to explain the high reactivity and alpha-selectivity. The N-phthalyl group was removed by treatment with methylhydrazine acetate, of which Neu alpha-Gal units can be readily applicable to the synthesis of a variety of N-linked oligosaccha-rides.
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