期刊
NATURE GENETICS
卷 37, 期 12, 页码 1317-1319出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1673
关键词
-
资金
- Telethon [GJT030477] Funding Source: Medline
A SNP in the gene PTPN22 is associated with type 1 diabetes, rheumatoid arthritis, lupus, Graves thyroiditis, Addison disease and other autoimmune disorders. T cells from carriers of the predisposing allele produce less interleukin-2 upon TCR stimulation, and the encoded phosphatase has higher catalytic activity and is a more potent negative regulator of T lymphocyte activation. We conclude that the autoimmune-predisposing allele is a gain-of-function mutant.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据