期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 82, 期 5, 页码 377-380出版社
SPRINGER JAPAN KK
DOI: 10.1532/IJH97.05097
关键词
asymmetric division; niche; APC; cell polarity
类别
资金
- NIDDK NIH HHS [P01 DK53074] Funding Source: Medline
The balance between stem cell and differentiating cell populations is critical for the long-term maintenance of tissue renewal for cell types derived from adult stem cell lineages such as blood, skin, intestinal epithelium, and sperm. To keep this balance, stem cells have the potential to divide asymmetrically, producing one daughter cell that maintains stem cell identity and one daughter cell that initiates differentiation. In many adult stem cell systems, the maintenance, proliferation, and number of stem cells appear to be controlled by the microenvironment, or niche. The Drosophila male and female germ line provide excellent model systems in which to study asymmetric stem cell divisions within the stem cell niche. In addition to signals from the niche that specify stem cell self-renewal, the stem cells themselves have elaborate cellular mechanisms to ensure the asymmetric outcome of cell division.
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