Olanzapine versus propranolol in essential tremor

Purpose: In this study, we evaluated the anti-tremor effect of olanzapine in patients with essential tremor (ET). Material and methods: Thirty-eight patients with ET affecting upper limbs underwent a randomized, crossover study with olanzapine (20 mg/day) and propranolol (120 mg/day). Evaluation (baseline and I month after each drug) was done by using the tremor clinical rating scale and a self-reported disability scale. Results: We did not find statistical difference in all tremor parameters before treatment in two groups. Both drugs improved essential tremor parameters. However, olanzapine significantly improved all tremor parameters except hygiene as compared to propronalol. Conclusion: These results suggest that olanzapine might be efficacious for essential tremor. Further clinical trials are indicated to establish the efficacy of olanzapine in patients with ET. (c) 2005 Elsevier B.V. All rights reserved.