期刊
REDOX REPORT
卷 10, 期 6, 页码 319-323出版社
TAYLOR & FRANCIS LTD
DOI: 10.1179/135100005X83699
关键词
thiol-disulfide oxidoreductase; fetal development; sulfhydryl oxidase; bovine fetal serum; QSOX
The participation of thiol-oxidoreductases such as thioredoxin during implantation, embryogenesis and fetal development has been extensively studied. Here, we analyzed the expression of the thioredoxin superfamily enzyme quiescin Q6/sulfhydryl oxidase (QSOX) during development. Results show that QSOX is present in fetal bovine serum (4 months' gestation), but its levels decrease with time after birth (from P1 to P60). We also demonstrate that a sulfhydryl oxidase activity correlates with QSOX expression in such sera, suggesting a putative role in the redox modulation of developmental programs.
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