期刊
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
卷 125, 期 12, 页码 1005-1008出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/yakushi.125.1005
关键词
Salix matsudana; arachidonic acid; 12-hydroxyeicosatetraenoic acid; thromboxane B-2
Apigenin 7-O-beta-D-glucopyranuronide (1), luteolin 7-O-beta-D-glucopyranuronide (2), m-hydroxybenzyl beta-D-glucoside (3), and chrysoeriol 7-O-beta-D-glucopyranuronide (4) were isolated for the first time from the leaves of Salix matsudana. Furthermore, the effects of compounds 1, 2 and 3 on arachidonic acid metabolism were studied. These compounds inhibited significantly the production of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE). In addition, the aglycon apigenin inhibited not only 12-HETE but also thromboxane B-2 (TXB2). The effect of compound (4) on arachidonic acid metabolism is now under investigation.
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