期刊
SCIENCE
卷 310, 期 5753, 页码 1490-1492出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1119419
关键词
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资金
- NIDCD NIH HHS [F31 DC05864, R01 DC00232] Funding Source: Medline
Congenital deafness results in abnormal synaptic structure in endings of the auditory nerve. If these abnormalities persist after restoration of auditory nerve activity by a cochlear implant, the processing of time-varying signals such as speech would likely be impaired. We stimulated congenitally deaf cats for 3 months with a six-channel cochlear implant. The device used human speech-processing programs, and cats responded to environmental sounds. Auditory nerve fibers exhibited a recovery of normal synaptic structure in these cats. This rescue of synapses is attributed to a return of spike activity in the auditory nerve and may help explain cochlear implant benefits in childhood deafness.
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