期刊
ANNALS OF THORACIC SURGERY
卷 93, 期 4, 页码 1331-1339出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.athoracsur.2011.06.107
关键词
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资金
- Johnston-Wright Endowment, University of Kentucky, Department of Surgery
Acute respiratory distress syndrome (ARDS) is characterized by an acute inflammatory response that compromises alveolar-capillary membrane integrity. Clinical symptoms include refractory hypoxemia, noncardiogenic edema, and decreased lung compliance. The purpose of this review is to summarize the different ARDS large-animal models in terms of similarity to the clinical disease and underlying pathophysiology. The repeated lavage, oleic acid, endotoxin, and smoke/burn ARDS models will be discussed in this review. While each model has significant benefits, none is without weaknesses. Thus, the choice of large-animal ARDS model must be carefully considered based upon the study focus and investigative team experience. (Ann Thorac Surg 2012;93:1331-39) (C) 2012 by The Society of Thoracic Surgeons
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