期刊
TETRAHEDRON LETTERS
卷 46, 期 49, 页码 8471-8474出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.10.020
关键词
multicomponent reactions; Strecker reaction; aminonitriles; aldehydes; amines
The multicomponent Strecker reaction using trimethylsilyl cyanide was accomplished without any type of Lewis acid. The reaction performed in acetonitrile as solvent gave excellent results for any class of aldehydes (aromatic or aliphatic), Lis well as amines (aromatic or aliphatic). In many cases, alpha-artimonitrile product was isolated pure after the usual work-up, with quantitative chemical yields. A comparison between different solvents indicated that acetonitrile is the best choice. The rate comparison using different Lewis acids showed that all of them catalyzed the reaction in a similar extent, the difference with the acid Lewis-free being minimal. (c) 2005 Elsevier Ltd. All rights reserved.
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