期刊
TETRAHEDRON LETTERS
卷 46, 期 49, 页码 8521-8524出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.10.005
关键词
-
资金
- Biotechnology and Biological Sciences Research Council [B18337] Funding Source: researchfish
A series or non-symmetrical tri- and tetra-substituted ureas have been prepared to mimic the rigid tetracyclic core of estradiol. Tetra-substituted ureas were prepared by a five-step protocol, involving activation and displacement of a carbonyldiimidazole adduct in 48-67% overall yield. This method was unsuccessful for tri-substituted ureas, which were prepared in 42-74% yields by an alternative four-step method, which included a one-pot 4-nitrophenyl carbamate form ation/displacement sequence. (c) 2005 Elsevier Ltd. All rights reserved.
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