期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 493, 期 1, 页码 99-110出版社
WILEY
DOI: 10.1002/cne.20723
关键词
neuromodulation; decision making; utility; optimization; orbitofrontal cortex; anterior cingulate cortex
资金
- NIMH NIH HHS [R01 MH55309, R01 MH58480, P50 MH62196] Funding Source: Medline
Historically, the locus coeruleus-norepinephrine (LC-NE) system has been implicated in arousal, but recent findings suggest that this system plays a more complex and specific role in the control of behavior than investigators previously thought. We review neurophysiological, anatomical, and modeling studies in monkey that support a new theory of LC-NE function. LC neurons exhibit two modes of activity, phasic and tonic. Phasic LC activation is driven by the outcome of task-related decision processes and is proposed to facilitate ensuing behaviors and to help optimize task performance. When utility in the task wanes, LC neurons exhibit a tonic activity mode, associated with disengagement from the current task and a search for alternative behaviors. Monkey LC receives prominent, direct inputs from the anterior cingulate (ACC) and orbitofrontal cortices (OFC), both of which are thought to monitor task-related utility. We propose that these prefrontal areas produce the above patterns of LC activity to optimize the utility of performance on both short and long time scales.
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