期刊
EMBO JOURNAL
卷 24, 期 23, 页码 3996-4006出版社
WILEY
DOI: 10.1038/sj.emboj.7600860
关键词
Alzheimer's disease; amyloid-beta precursor protein; APP; structural and functional relationships
Proteolytic processing of the amyloid-beta precursor protein (APP) generates the A beta amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance to particular structures identified in the protein.
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