期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 70, 期 25, 页码 10227-10237出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo0511896
关键词
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Molecular clips functionalized by phosphonate or phosphate groups bind thiamine diphosphate (TPP) and S-adenosylmethionine (SAM) with high affinity in water; both sulfur-based cofactors transfer organic groups to biomolecules. For TPP, various analytical tools point toward a Simultaneous insertion of both heterocyclic rings into the electron-rich clip cavity. Similarly, SAM is also embedded with its sulfonium moiety inside the receptor cavity. This paves the way for enzyme models and direct interference with enzymatic processes.
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