期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 338, 期 1, 页码 617-626出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2005.08.111
关键词
oxygenase; signalling; oxygen; iron; hypoxia inducible factor; transcription
资金
- Biotechnology and Biological Sciences Research Council [B18672, BBS/B/07683] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [B18672, BBS/B/07683] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Analysis of oxygen sensitive pathways that regulate the hypoxia inducible factor (HIF) transcriptional system has revealed a novel role for oxygenases in signalling hypoxia. The enzymes, which catalyse hydroxylation of specific prolyl and asparaginyl residues in the regulatory HIF-alpha subunits, belong to the superfamily of non-haem Fe(II)-dependent oxygenases that use the citric acid cycle intermediate 2-oxoglutarate (2OG) as a co-substrate. We review biochemical and physiological data that demonstrate a central role for these oxygenases in integrating multiple signals that coordinate cellular responses to hypoxia. (c) 2005 Elsevier Inc. All rights reserved.
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