期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 338, 期 1, 页码 610-616出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2005.08.193
关键词
hypoxia-inducible factor 1; hypoxia; hydroxylation; transcriptional regulation; dioxygenase; oxygen sensing
Hypoxia-inducible factor I (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction. (c) 2005 Elsevier Inc. All rights reserved.
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