期刊
SCIENCE
卷 310, 期 5754, 页码 1661-1665出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1120367
关键词
-
资金
- Engineering and Physical Sciences Research Council [GR/A10274/01] Funding Source: researchfish
Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads.
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