期刊
SCIENCE
卷 310, 期 5754, 页码 1683-1686出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1117468
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资金
- NIGMS NIH HHS [F32 GM067408, F32 GM067408-02, 1 R01 GM/CA655591-01, F32 GM067408-01A1, 1 F32 GM67408-01A1] Funding Source: Medline
We report the discovery of a checkpoint that monitors synapsis between homologous chromosomes to ensure accurate meiotic segregation. Oocytes containing unsynapsed chromosomes selectively undergo apoptosis even if a germline DNA damage checkpoint is inactivated. This cutting mechanism is specifically activated by unsynapsed pairing centers, cis-acting chromosome sites that are also required to promote synapsis in Caenorhabditis elegans. Apoptosis due to synaptic failure also requires the C. elegans homolog of PCH2, a budding yeast pachytene checkpoint gene, which suggests that this surveillance mechanism is widely conserved.
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