期刊
NEUROLOGY
卷 65, 期 11, 页码 1823-1825出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000187075.81589.fd
关键词
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资金
- NINDS NIH HHS [R01 NS36711-05] Funding Source: Medline
- Telethon [GTF04007] Funding Source: Medline
Brain-derived neurotrophic factor ( BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.
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