期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 127, 期 49, 页码 17277-17285出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja0543090
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资金
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
- NIGMS NIH HHS [P41 GM066354, R01 GM034504, GM66354, GM34504] Funding Source: Medline
We present an NMR study on the structure of a DNA fragment of the human telomere containing three guanine-tracts, d(GGGTTAGGGTTAGGGT). This sequence forms in Na+ solution a unique asymmetric dimeric quadruplex, in which the G-tetrad core involves all three G-tracts of one strand and only the last X-end G-tract of the other strand. We show that a three-repeat human telomeric sequence can also associate with a single-repeat human telomeric sequence into a structure with the same topology that we name (3 + 1) quadruplex assembly. In this G-quadruplex assembly, there are one syn(.)syn(.)syn(.)anti and two anti(.)anti(.)anti(.)syn G-tetrads, two edgewise loops, three G-tracts oriented in one direction and the fourth oriented in the opposite direction. We discuss the possible implications of the new folding topology for understanding the structure of telomeric DNA, including Hoop formation, and for targeting G-quadruplexes in the telomeres.
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