期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 11, 期 46, 页码 7323-7329出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v11.i46.7323
关键词
Pouchitis; Innate immunity; Single nucleotide polymorphisms; CD14; TLR9
资金
- Tramedico BV, the Netherlands
- Falk Foundation, Germany
- Foundation of Immunogenetics, The Netherlands
- Department of Internal Medicine of the VU University Medical Centre, the Netherlands
AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity. METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 + 896A>G, TLR9 -1237T>C, TLR9 + 2848G>A, and IRAKM + 22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients, 35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls. RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients. However, a significant difference in carriership frequency of the TLR9 -1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [ P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6]. This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians. Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4-12.3). CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.
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