期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 11, 期 46, 页码 7302-7307出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v11.i46.7302
关键词
Human leukocyte antigen; Genetic polymorphism; DQB1*0301; DRB1*1101; Hepatitis C virus; Spontaneous clearance; Meta-analysis
资金
- National Natural Science Foundation of China [30200232]
AIM: To assess the associations of human leukocyte antigen (HLA) class II DQB1*0301 and/or DRB1*1101 allele with spontaneous hepatitis C virus (HCV) clearance by meta-analysis of individual dataset from all studies published till date. METHODS: To clarify the impact of HLA class II polymorphisms on viral clearance, we performed a meta-analysis of the published data from 11 studies comparing the frequencies of DQB1*0301 and DRB1*1101 alleles in individuals with spontaneous resolution to those with persistent infection. As we identified the heterogeneity between studies, summary statistical data were calculated based on a random-effect model. RESULTS: Meta-analyses yielded summary estimates-odds ratio (OR) of 2.36 [95% CI (1.62, 3.43), P < 0.00001] and 2.02 [95% CI (1.56, 2.62), P < 0.00001] for the effects of DQB1*0301 and DRB1*1101 alleles on spontaneous clearance of HCV, respectively. CONCLUSION: These results support the hypothesis that specific HLA class II alleles might influence the susceptibility or resistance to persistent HCV infection. Both DQB1*0301 and DRB1*1101 are protective alleles and present HCV epitopes more effectively to CD4(+)T lymphocytes than others, and subjects with these two alleles are at a lower risk of developing chronic HCV infection. Large, multi-ethnic confirmatory and well-designed studies are needed to determine the host genetic determinants of HCV infection. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据