期刊
JOURNAL OF NEUROSCIENCE
卷 25, 期 50, 页码 11637-11644出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3604-05.2005
关键词
imaging; somatosensory; oxytocin; olfactory; maternal; lactation
资金
- NIDA NIH HHS [R01 DA13517, R01 DA013517] Funding Source: Medline
Oxytocin is released in the maternal brain during breastfeeding and may help strengthen the mother-infant relationship. Here, we used functional magnetic resonance imaging to determine whether oxytocin modulates brain activity in postpartum day 4-8 dams receiving suckling stimulation. During imaging sessions, dams were exposed to pup suckling before and after administration of an oxytocin receptor antagonist. Another group of dams received oxytocin alone. Changes in brain activation in response to suckling closely matched that elicited by oxytocin administration. The overlapping brain areas included the olfactory system, nucleus accumbens, insular cortex, prefrontal cortex, ventral tegmental area, cortical amygdala, and several cortical and hypothalamic nuclei. Blockade of oxytocin receptors largely attenuated activation in these regions. The data suggest that oxytocin may strengthen mother-infant bond formation partly by acting through brain areas involved in regulating olfactory discrimination, emotions, and reward.
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