期刊
JOURNAL OF IMMUNOLOGY
卷 175, 期 12, 页码 8415-8423出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.175.12.8415
关键词
-
类别
资金
- PHS HHS [P01-A148238, T32-A107447-11] Funding Source: Medline
HIV-1 replication is associated with reduced or absent HIV-1-specific CD4(+) T cell proliferation and skewing of HIV-1-specific CD4(+) T cells toward an IFN-gamma-producing, CCR7(-) phenotype. The CCR7- T cell population is heterogeneous and can be subdivided based on the expression of CD57. Although CD57 expression on CD8(+) T cells is associated with proliferation incompetence and replicative senescence, less is known about the function of CD57(-)expressing CD4(+) T cells. In this study, the frequency, phenotype, and function of CD57(+)CD4(+) T cells were evaluated in 25 HIV-1-infected subjects and 10 seronegative controls. CD57(+)CD4(+) T cells were found to be proliferation incompetent, even after strong mitogen stimulation. Percentages of CD4(+) T cells that expressed CD57 were significantly higher in untreated HIV-1-infected subjects than in HIV-1-seronegative donors, and CD57 expression did not normalize in subjects receiving at least 6 mo of effective antiretroviral therapy. CD57 was predominately expressed on the CCR7(-) fraction of the CD4(+) T cell compartment and accounted for the majority of cells in the CCR7(-)CD45RA(+) population from untreated HIV-1-infected subjects. HIV-1-specific CD4(+) T cells producing only IFN-gamma had the highest expression of CD57, whereas few cells producing IL-2 alone expressed CD57. These findings further define a novel population of proliferation-incompetent CD4(+) T cells that are generated in the presence of chronic Ag exposure. A better understanding of the generation and persistence of CD57(+) T cells in HIV-1 infection could provide important insights into the immunopathogenesis of this disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据