期刊
STEROIDS
卷 70, 期 14, 页码 954-959出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2005.07.004
关键词
sponge; Lamellodysidea herbacea; polyhydroxysterol; antifungal activity
Chemical investigation of the dichloromethane extract of the Red Sea marine sponge Lamellodysidea herbacea led to the isolation of four novel polyhydroxysteroids: cholesta-8-en-3 beta,5 alpha,6 alpha,25-tetrol (1), cholesta-8(14)-en-3 beta,5 alpha,6 alpha,25-tetrol (2), cholesta-8,24-dien-3 beta,5 alpha,6 alpha-triol (3), and cholesta-8(14),24-dien-30,5 alpha,6 alpha-triol (4). Their structures were identified through 1D and 2D NMR studies. Relative stereochemistries were established by analysis of chemical shifts, coupling constants, and NOESY correlations. Compounds 3-4 showed antifungal activity against Candida tropicalis, with an inhibition diameter of 13 and 11 mm at 10 mu g/disc, respectively. (c) 2005 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据