期刊
CELL
卷 123, 期 6, 页码 1037-1050出版社
CELL PRESS
DOI: 10.1016/j.cell.2005.09.034
关键词
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资金
- NIGMS NIH HHS [F32 GM067408-02, F32 GM067408, R01 GM53804, R01 GM655591, F32 GM067408-01A1, R01 GM065591, GM067408, R01 GM053804] Funding Source: Medline
We have investigated the role of pairing centers (PCs), cis-acting sites required for accurate segregation of homologous chromosomes during meiosis in C. elegans. We find that these sites play two distinct roles that contribute to proper segregation. Chromosomes lacking PCs usually fail to synapse and also lack a synapsis-independent stabilization activity. The presence of a PC on just one copy of a chromosome pair promotes synapsis but does not support synapsis independent pairing stabilization, indicating that these functions are separable. Once initiated, synapsis is highly processive, even between nonhomologous chromosomes of disparate lengths, elucidating how translocations suppress meiotic recombination in C. elegans. These findings suggest a multistep pathway for chromosome synapsis in which PCs impart selectivity and efficiency through a kinetic proofreading mechanism. We speculate that concentration of these activities at one region per chromosome may have coevolved with the loss of a point centromere to safeguard karyotype stability.
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