期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 493, 期 3, 页码 321-333出版社
WILEY-LISS
DOI: 10.1002/cne.20722
关键词
neurosphere; neural stem cell; plasticity; transdifferentiation
资金
- NHLBI NIH HHS [HL70143] Funding Source: Medline
- NINDS NIH HHS [NS041472, R01 NS037556, R01 NS037556-09, NS37556] Funding Source: Medline
To the extent that their fate choice and differentiation processes can be understood and manipulated, neural stem cells represent a promising therapeutic tool for a variety of neuropathologies. We have previously shown that mature astrocytes possess neural stem cell attributes, and can give rise to neurons through the formation of multipotent neurosphere clones. Here we show that relatively mature neurons generated from neurospheres derived from postnatal subependymal zone or cerebellar cortex undergo a phenotypic transformation into astrocytes that coincides with the appearance of a nonfused, hybrid cell type that shares the morphology, antigenicity, and physiology of both neurons and astrocytes. We refer to this astrocyte/neuron hybrid as an asteron, and hypothesize that it represents an intermediate step in the trans- or dedifferentiation of neurons into astrocytes. The present finding suggests that seemingly terminally differentiated neural cells may in fact represent points along a bidirectionally fluid continuum of differentiation, with intermediate points represented by hybrid cells coexpressing phenotypic markers of more than one lineage.
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