期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1719, 期 1-2, 页码 82-101出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2005.11.003
关键词
exocrine gland; endocrine gland; enzyme; hormone; Ca2+; synchronization
资金
- NIDDK NIH HHS [1R01 DK-63443-01] Funding Source: Medline
Glands were. the first type of tissues in which the permissive role of gap junctions in the cell-to-cell transfer of membrane-impermeant molecules was shown. During the 40 years that have followed this seminal finding, gap junctions have been documented in all types of multicellular secretory systems, whether of the exocrine, endocrine or pheromonal nature. Also, compelling evidence now indicates that gap junction-mediated coupling, and/or the connexin proteins per se, play significant regulatory roles in various aspects of gland functions, ranging from the biosynthesis, storage and release of a variety of secretory products, to the control of the growth and differentiation of secretory cells, and to the regulation of gland morphogenesis. This review summarizes this evidence in the light of recent reports. (C) 2005 Elsevier B.V. All rights reserved.
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