期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 102, 期 51, 页码 18264-18268出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0509541102
关键词
acid-degradable particle; drug delivery; targeted vaccine
资金
- NIBIB NIH HHS [R01 EB005824, R01-EB005824-01] Funding Source: Medline
Activating the immune system to trigger a specific response is a major challenge in vaccine development. In particular, activating sufficient cytotoxic T lymphocyte-mediated cellular immunity, which is crucial for the treatment of many diseases including cancer and AIDS, has proven to be especially challenging. In this study, antigens were encapsulated in acid-degradable polymeric particle carriers to cascade cytotoxic T lymphocyte activation. To target dendritic cells, the most potent antigen-presenting cells, the particle carriers, were further conjugated with monoclonal antibodies. A series of ex vivo and in vivo studies have shown increased receptor-mediated uptake of anti body-conjugated particles by dendritic cells as well as migration of particle-carrying dendritic cells to lymph nodes and stimulation of naive T cells leading to enhanced cellular immune response as confirmed by specific cell lysis and IFN-gamma secretion.
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