期刊
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
卷 294, 期 23, 页码 3019-3023出版社
AMER MEDICAL ASSOC
DOI: 10.1001/jama.294.23.3019
关键词
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Protein-polysaccharide conjugate vaccines that protect against Haemophilus influenzae type b (Hib), serogroup C Neisseria meningitidis, and multiple capsular serotypes of Streptococcus pneumoniae have had a major impact on invasive bacterial disease in childhood when incorporated into routine infant immunization schedules. However, effectiveness data from the United Kingdom suggest that primary infant immunization alone may not be associated with long-term protection. Both immunological priming and antibody persistence are important aspects of long-term protection induced by these vaccines. An improved understanding of the immunobiology of the B-cell response to these vaccines may direct development of immunization strategies that provide sustained protection.
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