期刊
LIFE SCIENCES
卷 78, 期 5, 页码 485-494出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2005.09.004
关键词
drug discovery; natural products; Mycobacterium tuberculosis; dormancy; bioassay-guided fractionation
The challenge of discovering new, urgently needed anti-TB drugs from natural sources requires a truly interdisciplinary research. Cutting-edge mycobacteriology and innovative natural products chemistry tools have to be developed and employed in tandem, in order to meet these demands. The present review provides cross-linkage to the most recent literature on anti-TB active natural products and summarizes the recent developments in both fields and their potential to impact the early steps of the TB drug discovery process. (c) 2005 Elsevier Inc. All rights reserved.
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