期刊
NEURON
卷 48, 期 6, 页码 933-947出版社
CELL PRESS
DOI: 10.1016/j.neuron.2005.11.031
关键词
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资金
- NEI NIH HHS [P30 EY12196] Funding Source: Medline
- NHGRI NIH HHS [F31 HG000180] Funding Source: Medline
- NICHD NIH HHS [F31 HD049320, P01 HD036379, R01 HD051936] Funding Source: Medline
- NIDDK NIH HHS [R21 DK618021, R01 DK067826] Funding Source: Medline
The lower rhombic lip (LRL) is a germinal zone in the dorsal hindbrain productive of tangentially migrating neurons, streaming extramurally (mossy fiber neurons) or intramurally (climbing fiber neurons). Here we show that LRL territory, operationally defined by Wnt1 expression, is parceled into molecular subdomains predictive of cell fate. Progressing dorsoventrally, Lmx1a and Gdf7 expression identifies the primordium for hindbrain choroid plexus epithelial cells; Math 1, for mossy fiber neurons; and immediately ventral to Math1 yet within Wnt1(+)territory, a climbing fiber primordium dominated by Ngn1-expressing cells. Elimination of Pax6 results in expansion of this Ngn1(+) progenitor pool and reduction in the Math1(+) pool, with accompanying later enlargement of the climbing fiber nucleus and reductions in mossy fiber nuclei. Pax6 loss also disrupts Msx expression cell-nonautonomously, suggesting Pax6 may influence LRL progenitor identity indirectly through potentiating BMP signaling. These studies suggest that underlying the diversity and proportions of fates produced by the LRL is a precise suborganization regulated by Pax6.
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