期刊
LIFE SCIENCES
卷 78, 期 5, 页码 442-453出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2005.09.007
关键词
indole alkaloids; bioactive marine natural products; new drug leads
资金
- NIAID NIH HHS [R01 AI036596] Funding Source: Medline
The marine environment produces natural products from a variety of structural classes exhibiting activity against numerous disease targets. Historically marine natural products have largely been explored as anticancer agents. The indole alkaloids are a class of marine natural products that show unique promise in the development of new drug leads. This report reviews the literature on indole alkaloids of marine origin and also highlights our own research. Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, antiinflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism, and other pharmacological activities. (c) 2005 Elsevier Inc. All rights reserved.
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