期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1100, 期 1, 页码 108-115出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2005.09.017
关键词
HPLC; SFC; enantioselective chromatography; cbz derivatives; chiral amines; pharmaceuticals; preparative separations
The carbobenzyloxy (cbz) protecting group is evaluated for it's potential to enhance the resolution of chiral amine enantiomers using high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC). A series of cbz derivatives of commercially available racemates was prepared and analyzed by enantioselective chromatography using a variety of mobile phases and polysaccharide and Pirkle-type chiral stationary phases (CSPs). The cbz-derivatized product consistently demonstrated enhanced chiral resolution under HPLC and SFC conditions. Improved selectivity and resolution combined with an automated preparative HPLC or SFC system can lead to the rapid generation of highly purified enantiomers of desirable starting materials, intermediates or final products. (c) 2005 Elsevier B.V. All rights reserved.
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