期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
卷 1732, 期 1-3, 页码 76-81出版社
ELSEVIER
DOI: 10.1016/j.bbaexp.2005.11.002
关键词
ascorbic acid; transcript variant; gene promoter; cardiovascular system
资金
- NIDDK NIH HHS [1F32 DK062692] Funding Source: Medline
Uptake of vitamin C occurs through the Na+-dependent vitamin C transporters (SVCT1 and 2), the products of two separate genes. In cultured human vascular smooth muscle cells (hVSMC), we found expression of only the hSVCT2 transcript and identified an additional 5'-UTR transcript variant that we termed exon 1b, in addition to the previously described exon 1a. We cloned and tested the promoter functionality of the two genomic regions of the hSVCT2 upstream of these alternative first exons in hVSMC. Both demonstrated activity, and deletion constructs demonstrated that the minimal promoter regions were within similar to 100 bp relative to their adjacent exons. Published by Elsevier B.V.
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