期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1754, 期 1-2, 页码 132-150出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2005.08.027
关键词
parasite; protein kinase; development; drug discovery; inhibitor; Plasmodium; malaria; Trypanosoma; toxoplasma; theileria; Entamoeba
资金
- Medical Research Council [G120/746] Funding Source: Medline
- Medical Research Council [G120/746] Funding Source: researchfish
- MRC [G120/746] Funding Source: UKRI
The surge of interest in protein kinases as targets for chemotherapeutic intervention in a number of diseases such as cancer and neurodegenerative disorders has stimulated research aimed at determining whether enzymes of this class might also be considered as targets in the context of diseases caused by parasitic protists. Here, we present an overview of recent developments in this field, concentrating (i) on the benefits gained from the availability of genomic databases for a number of parasitic protozoa, (ii) on the emerging field of structure-aided design of inhibitors targeting protein kinases of parasitic protists, (iii) on the concept known as transmission-blockade, whereby kinases implicated in the development of the parasite in their arthropod vector might be targeted to interfere with disease transmission, and (iv) on the possibility of controlling parasitic diseases through the inhibition of host cell protein kinases that are required for the establishment of infection by the parasites. (c) 2005 Elsevier B.V. All rights reserved.
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