Optimal target search on a fast-folding polymer chain with volume exchange -: art. no. 260603

We study the search process of a target on a rapidly folding polymer (DNA) by an ensemble of particles (proteins), whose search combines 1D diffusion along the chain, Levy type diffusion mediated by chain looping, and volume exchange. A rich behavior of the search process is obtained with respect to the physical parameters, in particular, for the optimal search.