期刊
TETRAHEDRON LETTERS
卷 47, 期 1, 页码 27-30出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.10.120
关键词
6-aminopyrimidine; formaldehyde; dimedone; pyrido[2,3-d]pyrimidine; pyrimido[4,5-b]quinoline; basic catalyst; microwave irradiation
Pyridopyrimidine-spirocyclohexanetriones (5, 6) and pyrimido[4,5-b]quinolinones (8) were obtained in a three-component microwave-assisted reaction of 6-aminopyrimidin-4-ones (1) with dimedone (2) and formaldehyde solution or paraformaldehyde, respectively. A mechanism is proposed based on the presence of a basic catalyst (triethylamine in this case) and the fact that single condensation intermediates are isolated prior to the cyclization leading to the final products. (c) 2005 Elsevier Ltd. All rights reserved.
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