期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 103, 期 1, 页码 99-102出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2005.07.011
关键词
Croton flavens L.; leaf essential oil; anticancer activity; viridiflorene; germacrone; (E)-gamma-bisabolene
The leaf essential oil of Croton flavens L., a native plant from the Caribbean area used in traditional medicine, was extracted by hydrodistillation. The composition of the volatile fraction of this essential oil was determined by GC and GC-MS analyses. We have identified 47 compounds, of which viridiflorene (12.22%), germacrone (5.27%), (E)-gamma-bisabolene (5.25%) and beta-caryophyllene (4.95%) are the main components. The anticancer activity of this extract was tested on human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line DLD-1. Croton flavens leaf essential oil was found to be very active against both tumor cell lines, with a GI(50) of 27 +/- 4 mu g/ml for A-549 and 28 +/- 3 mu g/ml for DLD-1. Three compounds identified in the leaf essential oil, alpha-cadinol (3.97%), beta-elemene (1.53%) and alpha-humulene (1.06%) are cytotoxic against tumor cell lines. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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