期刊
BRAIN RESEARCH
卷 1067, 期 1, 页码 256-262出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2005.10.086
关键词
substantia nigra; dopaminergic neurones; nitric oxide; peroxynitrite; 3-nitrotyrosine; Parkinson's disease
资金
- Wellcome Trust Funding Source: Medline
The presence of 3-nitrotyrosine (3-NT) adducts in Lewy bodies in Parkinson's disease suggests a role for nitrative stress in dopaminergic cell death. Whether this is a direct effect of increased nitric oxide (NO) formation or requires its reaction with superoxide to form peroxynitrite is not clear. In the present study, we show that direct nigral administration of a NO donor, SNOG, in the rat produced only local toxicity to dopaminergic neurones prelabeled with fluorogold with no 3-NT formation. However, administration of a peroxynitrite donor, SIN-1, caused widespread damage to dopaminergic neurones and marked expression of 3-NT immunoreactivity. Importantly, dopaminergic cell loss and the expression of 3-NT were completely prevented when SIN-1 was co-administered with the NO/peroxynitrite scavenger, carboxy-PTIO. The results suggest that increased NO formation is not inherently toxic to dopaminergic neurons, but when both oxidative and nitrative stress combine to cause peroxynitrite formation, neurotoxicity occurs. (c) 2005 Elsevier B.V. All rights reserved.
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