期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 71, 期 1, 页码 62-69出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo051549p
关键词
-
资金
- NIGMS NIH HHS [GM070620, P50 GM069663-03, P50 GM069663, R01 GM070620, R01 GM070620-02] Funding Source: Medline
3-lodoindoles have been prepared in excellent yields by coupling terminal acetylenes with N,N-dialkyl-o-iodoanilines in the presence of a Pd/Cu catalyst, followed by an electrophilic cyclization of the resulting N,N-dialkyl-o-(1-alkynyl)anilines using I-2 in CH2Cl2. Aryl-, vinylic-, alkyl-, and silyl-substituted terminal acetylenes undergo this process to produce excellent yields of 3-iodoindoles. The reactivity of the carbon-nitrogen bond cleavage during cyclization follows the following order: Me > n-Bu, Me > Ph, and cyclohexyl > Me. Subsequent palladium-catalyzed.Sonogashira, Suzuki, and Heck reactions of the resulting 3-iodoindoles proceed smoothly in good yields.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据