期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 71, 期 1, 页码 397-400出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo0519615
关键词
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A simple two-step procedure for synthesizing functionalized benzhydrylamines is described. The first step involves a Suzuki-Miyaura coupling reaction between arylboronic acids and 3-chloro-3-arylacrylonitriles at 45 degrees C. A variety of boronic acids and substituted acrylonitriles can be used for the reaction. The resulting 3,3-diaryl-substituted acrylonitriles can be converted into their corresponding Boc-protected amines by catalytic hydrogenation.
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